Comparison of contemporary invasive and non-invasive <i>Streptococcus pneumoniae</i> isolates reveals new insights into circulating anti-microbial resistance determinants.

"data availability genome sequences are deposited in genbank under bioproject prjna857543 and the accession numbers and sample data are available in the supplementary material (data set s1). data availability genome sequences are deposited in genbank under bioproject prjna857543 and the accession numbers and sample data are available in the supplementary material (data set s1).; click here for additional data file 10 1128/aac 00785-23 suf2 dataset s1 aac 00785-23-s0002 csv all metadata.; click here for additional data file 10 1128/aac 00785-23 suf3 dataset s2 aac 00785-23-s0003 csv geno comp. data availability genome sequences are deposited in genbank under bioproject prjna857543"

"The authors declare no conflict of interest."

"We thank all microbiologists from the laboratories in the state of Victoria for sending invasive isolates of Streptococcus pneumoniae to the Microbiological Diagnostic Unit (MDU) and supporting invasive pneumococcal disease (IPD) surveillance in the state. We gratefully acknowledge the staff of the Monash Health Microbiology Laboratory, who contributed non-invasive isolates to the study. We also thank the laboratories that participated in the Controlling Superbugs State-wide Snapshot project, which was funded by the Melbourne Genomics Health Alliance (supported by the State Government of Victoria). We also thank all staff at the Department of Health, Victoria, for their coordination and funding of IPD surveillance. Additionally, we wish to thank the AMR laboratory staff of the MDU Public Health Laboratory, and Controlling Superbugs project team members Dr. Diane Daniels, Dr. Chris Connor, Madeline Russell, and Sandra Johnson for their contributions. MDU PHL is funded by the Victorian Government, Australia. This work was supported by NHMRC Partnership Project (GNT1149991). BPH is supported by NHMRC Investigator Grants (GNT1196103). The state-wide AMR snapshot was carried out as part of the ‘Controlling Superbugs 2’ study, funded by the Melbourne Genomics Health Alliance (supported by the State Government of Victoria)."