Targeting hypoxia-inducible factor-1 alpha suppresses <i>Helicobacter pylori</i>-induced gastric injury via attenuation of both <i>cag</i>-mediated microbial virulence and proinflammatory host responses.

"data availability statement the data that support the findings of this study are available in figshare at https://doi org/10 6084/m9 figshare 22154753 v2 noto jennifer (2023): milliplex cytokine/chemokine magnetic bead panel figshare. data availability statement the data that support the findings of this study are available in figshare"

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"We would like to acknowledge the following funding support through the National Institutes of Health: R01CA077955 (RMP), R01DK058587 (RMP), P01CA116087 (RMP), and P30DK058404 (RMP) as well as ANID FONDAP 152220002 (JCR) and the Science Foundation Ireland (CTT). We also acknowledge the following resources at Vanderbilt University Medical Center: Animal Care and Use Program, Division of Animal Care, Translational Pathology Shared Resource Core (NCI/NIH Cancer Center Support Grant P30CA68485), and Digestive Disease Research Center Tissue Morphology Core."