A novel rare variants association test for binary traits in family-based designs via copulas.

"the nrvat method is implemented in a software r package pedgflmm which is freely available at https://github com/houssoudossa/nrvatgflmm .; codes are also publicly available in github for reproducibility of the simulation scenarios of setting 1 at https://github com/houssoudossa/nrvat-simulation-code ."

"The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article."

"Funding: This work received received financial support from: the Canadian Statistical Sciences Institute (CANSSI) through a collaborative reseach team (CRT) grant.Fonds de recherche du Québec through the grant FRQS-CB-J1.The Eastern Quebec Schizophrenia and Bipolar Disorder study was funded by the Canadian Institutes of Health research (CIHR, grants MOP-74430, MOP-119408, MOP-114988 and PCG-155471) and its data management system was supported by the Canada Foundation for Innovation Leadership Opportunity Fund (grant 27592)."