Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.

"funding this work was supported by grants from the wellcome trust/royal society (101225/z/13/z) and mrc (mr/x008487/1) to m r b; and bbsrc (bb/t000031/1) to m r b and j m f availability of data and materials rna-seq data have been deposited in ncbi's gene expression omnibus under accession number gse238224.; publicly available chip-seq data were used for h3k9me2 (geo:gse84009) kdm4c (geo:gse93721) and mouse (geo:gse64252) and human (encode:encsr000avc) kdm4a. all remaining data and code associated with the manuscript is available via the github repository https://github com/mbrancolab/cheng_2023_vitc . availability of data and materials rna-seq data have been deposited in ncbi's gene expression omnibus under accession number gse238224"

"all remaining data and code associated with the manuscript is available via the github repository https://github com/mbrancolab/cheng_2023_vitc ."

"Declarations Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by grants from the Wellcome Trust/Royal Society (101225/Z/13/Z) and MRC (MR/X008487/1) to M.R.B.; and BBSRC (BB/T000031/1) to M.R.B. and J.M.F."