KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.

"Declarations Ethics approval and consent to participateThis study was performed in accordance with the Declaration of Helsinki. Requisite approval from the Medical Ethics Committee of affiliated hospital of Jiangnan University and written informed consent from patients were obtained prior to obtaining patient samples. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was financially supported by the National Natural Science Foundation of China (82303115), Youth Program of Wuxi Medical Foundation (Q202114), the Wuxi Taihu Lake Talent Plan, Wuxi Medical Key Discipline (No. ZDXK2021002) and Wuxi Medical Key Discipline (ZDXK2021002)."