Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations.

"data availability all tumor somatic sequencing data generated from mioncoseq has been uploaded to the database of genotypes and phenotypes (dbgap) [accession number phs000673 v1 p1]. file 1 (pdf 2694 kb) supplementary file 2 (xlsx"

"Declarations Conflict of interestThe authors have no relevant financial or non-financial interests to disclose. Ethics approvalThis research study was conducted retrospectively from data obtained for clinical or prior research purposes. The IRB at the University of Michigan Medical School approved this study with a HIPAA authorization waiver. Conflict of interest The authors have no relevant financial or non-financial interests to disclose."

"Funding Open access funding provided by EPFL Lausanne. National Institutes of Health Grant R01-NS119231 (CK). National Institutes of Health Grant R01-NS124607 (CK). National Institutes of Health Grant R01-NS110572 (SV). National Institutes of Health Grant R01-CA261926 (SV). DOD Grant CA201129P1 (CK). University of Michigan Chad Carr Pediatric Brain Tumor Center (CK, SV). The Evans Family (CK). ChadTough Defeat DIPG Foundation (CK, SV). Catching Up with Jack (CK). Pediatric Brain Tumor Foundation (CK). Prayers From Maria Foundation (CK). Michael Miller Memorial Foundation (CK). Morgan Behen Golf Classic (CK). Yuvaan Tiwari Foundation (CK). Sontag Foundation (SV). Alex Lemonade Stand Foundation (SV). Hyundai Hope Foundation (SV). National Institutes of Health Clinical Sequencing Exploratory Research Award Grant 1UM1HG006508 for PEDS-MIONCOSEQ Study (AC). École Polytechnique Fédérale de Lausanne (SMW)."