Safety and Outcome of High-Flow Nasal Oxygen Therapy Outside ICU Setting in Hypoxemic Patients With COVID-19.

"Dr. Endeman has received unrestricted research grants from Fisher and Paykel Healthcare (Auckland, New Zealand), La Roche Ltd. (Bazel, Switzerland), and Ventinova Medical B.V. (Eindhoven, The Netherlands). The remaining authors have disclosed that they do not have any potential conflicts of interest."

"This study was funded by unrestricted grants of the BOF Foundation and Indorama Ventures Europe BV. The funders had no role in the study design, execution, analysis, or decision to submit the results."

"This study was approved by the medical research ethics committee (Medical Research Ethics Committees United, MEC-U number W20.283), which waived the need for written informed consent due to the observational character of the study. However, some of the participating hospitals did obtain written informed consent if deemed necessary by local guidelines of institutional research committees. The study was registered on November 27, 2020, in the Dutch Trial Registry (LTR, NL9067). The study has been carried out in accordance with the Helsinki Declaration for medical research involving humans (). Before the start of the study analysis, we decided to include a more in-depth safety evaluation as originally preplanned and stated in the trial registry. Hence several endpoints were added to the analysis. The study design and setting were unchanged. This report follows the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines for cohort studies; The STROBE checklist of this study is depicted in Supplemental digital content (http://links.lww.com/CCM/H429) ()."