Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles.

"Competing interests The authors declare no competing interests."

"The iPSC-CP was gifted by K. Okita, M. Nakagawa, and S. Yamanaka (Center for iPS Cell Research and Application [CiRA], Kyoto University, Kyoto, Japan). We thank Morito Sakaue and Fumiko Hirai for development of the TEC and immunohistochemistry. This study was supported by Centers for Clinical Application Research on Specific Disease/Organ (type B) Grant NO. 17bm0304004h005 from the Japan Agency for Medical Research and Development (AMED). Author contributions: Conceptualization: W.A., K.S., N.T. and N.N. Methodology: W.A., K.S., D.H., R.C., H.F., N.T. and N.N. Investigation: S.N., H.H., G.J. and S.Y. Visualization: S.N., W.A., S.O. and N.N. Funding acquisition: T.N. and N.N. Project administration: W.A. and N.N. Supervision: N.N. Writing—original draft: S.N., W.A. and K.S. Writing—review & editing: W.A., D.H., T.N. and N.N."