Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.

"availability of data and materials many of the blood data analysed in twinsuk is available through geo gse62992 and gse121633 for methylation and ega egad00001001088 for gene expression. availability of data and materials many of the blood data analysed in twinsuk is available through geo gse62992"

"Declarations Ethics approval and consent to participateTwinsUK. Ethical approval was granted by the National Research Ethics Service London-Westminster, the St Thomas’ Hospital Research Ethics Committee (EC04/015 and 07/H0802/84). All research participants have signed informed consent prior to taking part in any research activities. KORA F4 and FF4. The KORA cohort ethical approval was granted by the ethics committee of the Bavarian Medical Association (REC reference numbers: F4: #06068, FF4: #06068) and all were carried out in accordance with the principles of the Declaration of Helsinki. This covers consent for the use of biological material, including genetics. All research participants have signed informed consent prior to taking part in any research activities. The KORA data protection procedures were approved by the responsible data protection officer of the Helmholtz Munich. LLS. In accordance with the Declaration of Helsinki, we obtained written informed consent from all participants prior to their entering the study. Good clinical practice guidelines were maintained. The study protocol was approved by the ethical committee of the Leiden University Medical Center before the start of the study (P01.113). Consent for publicationAll authors have read and approved the manuscript for publication. Competing interestsS.E.B. receives payments and options as a consultant to ZOE LIMITED. The other authors have no competing interests to declare. Competing interests S.E.B. receives payments and options as a consultant to ZOE LIMITED. The other authors have no competing interests to declare."

"Funding This project was supported by the European HDHL Joint Programming Initiative funding scheme DIMENSION project (BBSRC BB/S020845/1 and BB/T019980/1 to J.T.B.). K.S.S. acknowledges funding from the Medical Research Council (MR/M004422/1 and MR/R023131/1). X.Y. is funded by King's-China Scholarship Council PhD Scholarship. C.M. is funded by the Chronic Disease Research Foundation. The TwinsUK study is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), ZOE LIMITED, and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. The project DIMENSION, partnering site Helmholtz Munich, got financial support by a grant of the European HDHL Joint Programming Initiative funding scheme, administered by the Federal Ministry of Research in Germany, Grant No. 01EA1902A (R.W., M.W., C.G.). The project DIMENSION, partnering site LMU Munich, got financial support by a grant of the European HDHL Joint Programming Initiative funding scheme, administered by the Federal Ministry of Research in Germany, Grant No. 01EA1902B (F.H., J.L.). The Leiden Longevity Study has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2011) under grant agreement number 259679, the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology and the Netherlands Consortium for Healthy Ageing (Grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007 and 184.033.111)."