Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity.

"details on latent class models for identifying patient sdai trajectories and results are described in the supplementary material (see supplementary material data s1 and figure s1).; details on the definition of sdai thresholds and predefined choices to classify patients as well as sensitivity analyses are described in the supplementary material (supplementary data s2 supplementary table s3).; details on the constitution of the multivariate model for the structural functional and safety outcomes are outlined in the supplementary material (supplementary data s3).; details on das28 analyses are provided in the supplementary material (supplementary data s4 and table s5).; the description of the sensitivity analysis is provided in the supplementary material (supplementary data s4 supplementary tables s9 s10 s11 and s12).; additional file 1: supplementary data s1.; supplementary data s2.; supplementary data s3.; supplementary data s4."

"Declarations Ethics approval and consent to participateESPOIR cohort has been registered in ClinicalTrials.gov under the number NCT03666091). The institutional review board (ethics committee of Montpellier, France, no. 020307) approved the protocol, and all patients provided written informed consent. Consent for publicationAll patients provided written informed consent for participating to this study and accepted publication on the data collected. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding An unrestricted grant from Merck Sharp & Dohme was allocated for the first 5 years of the ESPOIR study. Two additional grants from the Institut National de la Santé et de la Recherche Médicale (INSERM) supported part of the biological database. The French Society of Rheumatology, Pfizer, AbbVie and Lilly also supported the ESPOIR cohort. No other funding source was necessary to conduct this study."