Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina.

"article plus supplemental information data and code availability the code used in all our analysis is available online ( www github com/jagorn/mea-analysis )."

"article plus supplemental information data and code availability the code used in all our analysis is available online ( www github com/jagorn/mea-analysis ). article plus supplemental information data and code availability the code used in all our analysis is available online ( www github com/jagorn/mea-analysis )."

"Declaration of interests D.D. reports grants from Foundation Fighting Blindness, USA and European Research Council, during the conduct of the study; D.D. is a co-inventor on patent #9193956 (Adeno-associated virus virions with variant capsid and methods of use thereof), with royalties paid to Adverum Biotechnologies. D.D. also has personal financial interests in Tenpoint Tx. and SparingVision, outside the submitted work. D.D., H.K., O.M., F.T., and E.O. are inventors on pending patent applications on methods to target A2 amacrine cells related to this work."

"We thank the Paris Vision Institute core facilities (Animal facility platform, Histology platform, Imaging platform) and particularly Camille Robert of the vector core facility for producing the AAVs. This work was supported ERC Starting Grant (REGNETHER 639888/DD), ERC Consolidator Grant (DEEPRETINA, 101045253), the 10.13039/501100004794Centre National de la Recherche Scientifique (CNRS), the 10.13039/501100001677Institut National de la Santé et de la Recherche Médicale (INSERM), AFM-Téléthon (PhD Fellowship H.K.), Foundation Fighting Blindness (PPA-0919-0772-INSERM), Sorbonne Université, LabEx LIFESENSES (ANR-10-LABX-65), IHU FOReSIGHT (ANR-18-IAHU-01), Paris Ile-de-France Region under « DIM Thérapie génique » initiative, Foundation Fighting Blindness (Program Project Award), ANR grants (ANR-18-CE37-0011 – DECORE, ANR-20-CE37-0018-04- Shooting Star, NUTRIACT, PerBaCo, RetNet4EC), AVIESAN-UNADEV (O.M.), and Retina France (O.M.). E.O. was supported by a fellowship from the Ecole des Neurosciences des Paris (ENP) Ile-de-France. Declaration of interestsD.D. reports grants from Foundation Fighting Blindness, USA and European Research Council, during the conduct of the study; D.D. is a co-inventor on patent #9193956 (Adeno-associated virus virions with variant capsid and methods of use thereof), with royalties paid to Adverum Biotechnologies. D.D. also has personal financial interests in Tenpoint Tx. and SparingVision, outside the submitted work. D.D., H.K., O.M., F.T., and E.O. are inventors on pending patent applications on methods to target A2 amacrine cells related to this work."