Blend to Limit OxygEN in ECMO: A RanDomised ControllEd Registry (BLENDER) Trial: Study Protocol and Statistical Analysis Plan.

"Competing interests Authors Rinaldo Bellomo, David Pilcher, Carol Hodgson, Andrew Udy and Ed Litton declare a conflict of interest as Editors of this journal."

"Aidan Burrell: Conceptualization, Methodology, Investigation, Writing - Original Draft, Visualization, Supervision, Funding acquisition. Sze Ng: Writing - Review & Editing, Resources, Project administration. Kelly Ottosen: Resources, Project administration. Michael Bailey: Methodology, Formal analysis, Funding acquisition. Hergen Buscher: Investigation, Supervision. John Fraser: Investigation, Supervision, Funding acquisition. Andrew Udy: Investigation, Funding acquisition. David Gattas: Investigation, Funding acquisition. Richard Totaro: Investigation, Supervision. Rinaldo Bellomo: Investigation, Supervision. Paul Forrest: Investigation. Emma Martin: Investigation. Liadain Reid: Resources, Project administration. Marc Ziegenfuss: Investigation. Glenn Eastwood: Investigation. Alisa Higgins: Writing - Review & Editing, Supervision, Funding acquisition. Carol Hodgson: Writing - Review & Editing, Supervision, Funding acquisition. Edward Litton: Investigation, Supervision. Priya Nair: Investigation. Neil Orford: Investigation, Supervision. Vince Pellegrino: Investigation. Kiran Shekar: Investigation. Tony Trapani: Resources, Supervision. David Pilcher: Conceptualization, Methodology, Investigation, Writing - Original Draft, Visualization, Supervision, Funding acquisition."

"Clinical trial registration: NCT0384108 The trial is approved by the Alfred Ethics committee (Project 88/19) and is registered with ClinicalTrials.gov (NCT03841084). Design: The BLENDER trial is a pragmatic, multicentre, registry-embedded, randomised clinical trial., registered at ClinicalTrials.gov (NCT03841084) and approved by The Alfred Hospital Ethics Committee project ID HREC/50486/Alfred-2019."