Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.

"Declarations Ethics approval and consent to participateThe animal study was reviewed and approved by the Care and Use Committee of Wuhan University Medical School and the National Institutes of Health guide for the care and use of Laboratory animals. Human brain specimens were collected at the Department of Neurosurgery of Zhongnan Hospital (Wuhan University, Wuhan, China) after the patients had given informed consent. All experiments involving human were performed in accordance with the Declaration of Helsinki and have been approved by Medical Ethics Committee, Zhongnan Hospital of Wuhan University (Scientific Ethical Approval [2019059]). Consent for publicationNot applicable. Competing interestsThe authors have no competing interests to report. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Competing interests The authors have no competing interests to report. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines."

"Funding This research is supported by the Natural Science Foundation of China (Grant No. 82171452), Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University (Grant No. ZNJC202230), 2023–2024 Key Project of Hubei Provincial Administration of Traditional Chinese Medicine (Grant No. ZY2023Z018), Medical Research Project of Wuhan Municipal Health Commission (No. S202103180002)."