Predictive value of the stress hyperglycemia ratio in dialysis patients with acute coronary syndrome: insights from a multi-center observational study.

"Declarations Ethics approval and consent to participateThis study was carried out following the Declaration of Helsinki and was approved by local institutional review boards, with a waiver of informed consent. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National High Level Hospital Clinical Research Funding (2022-NHLHCRF-YSPY-01), Capital’s Founds for Health Improvement and Research (No. 2022-1-4062), Science Foundation of China-Japan Friendship Hospital (No. 2020-HX-40), National Natural Science Foundation of China (No. 82270352), Beijing Research Ward Construction Clinical Research Project (no. 2022-YJXBF-04-03), Chinese Society of Cardiology’s Foundation (No. CSCF2021B02), and National Key Clinical Specialty Construction Project (2020-QTL-009)."

"The present study employed data obtained from the CRUISE-R (Coronary Revascularization in Patients On Dialysis in China-Retrospective) cohort study (ClinicalTrials.gov NCT05841082). The CRUISE-R study sought to undertake a comprehensive, observational, and multi-center registry investigation in China, targeting dialysis patients who were afflicted with coronary artery disease. The study’s principal objectives were to scrutinize the clinical features, therapeutic approaches, and prognosis of this particular patient population. A standardized protocol for patient selection was established with specific criteria and procedures, ensuring a uniform approach across all participating centers. The necessary information for screening criteria was easily available in electronic health records. All investigators involved in patient recruitment received unified training on the standardized screening criteria to reduce inter-center variability. Timely meetings and communication channels were established to address questions or concerns. Between January 2015 and June 2021, a total of 455,617 cardiac catheterizations were retrospectively evaluated in 30 tertiary medical centers, which were distributed across 12 provinces in China (Additional file 1: eAppendix 1). Exclusion criteria were rigorously applied, including patients who did not receive dialysis therapy or received dialysis therapy for less than 3 months (n = 453,421), those without any coronary stenosis exceeding 50% (n = 328), and individuals with other indications for coronary angiography (such as surgical interventions, valve diseases, or kidney transplants) (n = 87). For readmitted patients, only data from their initial admission were analyzed, with subsequent readmissions documented as “readmission” events (n = 532). Overall, the CRUISE-R study enlisted 1,249 dialysis patients suffering from obstructive coronary artery disease. The CRUISE-R registry study was carried out following the Declaration of Helsinki and was approved by local institutional review boards, with a waiver of informed consent. In the present analysis, we additionally eliminated 80 individuals with a diagnosis of stable angina and 455 patients with incomplete data on ABG or HbA1c. (Fig. ) This study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement."