An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease.

"data availability hepatic bulk rna-seq data are deposited in the european nucleotide archive ( https://www ebi ac uk/ena ; study accession number: prjeb58625 ). data availability hepatic bulk rna-seq data are deposited in the european nucleotide archive ( https://www ebi ac uk/ena ; study accession number: prjeb58625"

"Competing interests T.J.K. serves as a consultant for or has received speakers’ fees from Resolution Therapeutics, Clinnovate Health, Perspectum and Incyte Corporation. P.R. serves as a consultant for Merck and has received research grant funding from Genentech. J.A.F. serves as a consultant or advisory board member for Resolution Therapeutics, Kynos Therapeutics, Ipsen, Redx Pharma, River 2 Renal Corp., Stimuliver, Galecto Biotech, Global Clinical Trial Partners and Guidepoint and has received research grant funding from Intercept Pharmaceuticals and Genentech. A.J.-J. is an employee and stock owner at NeoGenomics. I.N.G. serves as an advisory board member for Resolution Therapeutics and has received research grant funding from Gilead Sciences. M.D.M. and D.R.D. have a controlling shareholder interest in Biodev Ltd. The remaining authors declare no competing interests."

"We are grateful to the following for assistance: L. McMahon, M. McNeil (PMS-IC)—project management, data compliance and security, workspace provision; B. Hartzoulakis (Eagle Genomics) and D. Harbison (PMS-IC)—acquisition of funding; Y. Staeva (Eagle Genomics)—project management; M. Jones (PMS-IC)—RNA-seq libraries; E. Coulston (PMS-IC)—administrative support; Edinburgh Clinical Research Facility Genetics Core/L. Murphy—RNA extraction; Edinburgh Genomics/M. Arno—RNA-seq; electronic Data Research and Innovation Service (eDRIS)/B. Bruce—clinical data access approval; Safe Havens: Lothian (C. Duncan, P. Linksted), Grampian (K. Wilde, J. Lumsden), GG&C (J. Burnie, S. McKenna)—EHR data retrieval; Lothian Bioresource (L. McLeod, C. Marshall)—human liver tissue access; E. McDowall (Institute of Genetics and Cancer)—‘shiny’ app hosting; SteatoSITE group (Chairperson L. Laidlaw: visiting fellow, University of Bournemouth). This work was funded by Innovate UK ((Precision medicine: impacting through innovative technology (Reference: TS/R017581/1; J.A.F. and T.J.K.)), Innovate UK Eureka (Reference: 105976; J.A.F. and T.J.K.), Guts UK Development Grant (Reference: DGO2019_16; J.A.F., T.J.K., P.R. and F.T.), industrial Collaborative Awards in Science and Engineering (iCASE) PhD studentship funded by the Medical Research Council Precision Medicine Doctoral Training Programme (Reference: MR/R01566X/1; M.J.-R.) and Galecto Biotech (M.J.-R.), Engineering and Physical Sciences Research Council (EPSRC) Innovation Fellowship (Reference: EP/S001921/1; F.M.), EPSRC New Investigator Award (Reference: EP/R035350/1; F.M.), UK Research and Innovation Engineering Biology Transition Award (Reference: BB/W014610/1; F.M.), Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund (Reference: 204804/Z/16/Z; L.B.), EPSRC Postdoctoral Fellowship (Reference: EP/P017134/1; L.B.) and MRC Senior Clinical Fellowship (Reference: MR/W015919/1; P.R.)."