Phenotypic variability in two female siblings with oocyte maturation arrest due to a TUBB8 variant.

"data availability the sequence data during the current study are available in the ncbi sra under accession number prjna909219 ( https://www ncbi nlm nih gov/sra/? data availability the sequence data during the current study are available in the ncbi sra under accession number prjna909219"

"Declarations Ethics approval and consent to participateAll procedures were in accordance with the Declaration of Helsinki. The study protocol was approved by the ethics committee of the Second Affiliated Hospital of Zhengzhou University (reference No. 2022373). All patients signed written informed consent. Consent for publicationNot Applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the Medical Science and Technology Project of Henan Province, China (Grant number: LHGJ20200421), and the Clinical Research Special Fund of Wu Jieping Medical Foundation (Grant number: 320.6750.18558(9))."