Cardiac output, cerebral blood flow and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation: design and rationale of the CAPITA study.

"Conflict of interest C.B.L.M. Majoie oie has received funds from CVON/Dutch Heart Foundation, Stryker, European Commission, Healthcare Evaluation Netherlands and TWIN Foundation (unrelated to this project; all paid to his institution) and is (minority interest) shareholder of Nicolab. J.E.F. Moonen has been appointed as a postdoctoral researcher by the Netherlands Consortium of Dementia Cohorts, which is funded by the Deltaplan Dementie from the ZonMw Memorabel Programme (project no. 73305095005) and Alzheimer Netherlands. J.J. Piek is Editor-in-Chief of the Netherlands Heart Journal. R. Delewi has received educational fees from Boston Scientific and Edwards Lifesciences and is Editor of the Netherlands Heart Journal. A.C. van Nieuwkerk, K.I. Hemelrijk, E.E. Bron, A.E. Leeuwis, M.J.A.P. Daemen, A. de Sitter, B.J. Bouma, W.M. van der Flier, J. Baan and G.J. Biessels declare that they have no competing interests."

"Funding This work was supported by the Heart-Brain Connection Crossroad Consortium of the Dutch CardioVascular Alliance. We acknowledge support from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation (CVON 2018-28 & 2012-06 Heart Brain Connection), Dutch Federation of University Medical Centres (NFU), the Netherlands Organisation for Health Research and Development (ZonMw) and the Royal Netherlands Academy of Sciences (KNAW)."

"The prospective CAPITA study evaluates the effect of TAVI treatment on cardiac output, CBF, structural brain lesions and cognitive functioning. Prior to TAVI and at 3‑month follow-up, patients will undergo echocardiography (cardiac output, valve function, LV function), brain MRI (CBF using arterial spin labelling (ASL), white matter hyperintensities (WMH), structural lesions) and extensive neuropsychological testing. To evaluate longer-term haemodynamic and cognitive effects of TAVI, echocardiography and neuropsychological testing will be performed again 1 year after TAVI. Baseline measurements will be taken on the day before scheduled TAVI. Follow-up assessments will be performed during an outpatient clinic visit and are combined with a routine cardiologist consultation. Figure  displays the study timeline. The CAPITA study is registered at ClinicalTrials.gov (identifier NCT05481008).Fig. 2Timeline of CAPITA study. TAVI transcatheter aortic valve implantation, MRI magnetic resonance imaging"