Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1.

"Declarations Ethics approval and consent to participateAll experiments were performed in accordance with the guidelines of the Canadian Council on Animal Care and the University of British Columbia Animal Care Committee. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding T.P.S. is supported by an operating grant from the Canadian Institutes of Health Research (CIHR; #10677) and the Koerner Foundation. S.M.C. received support from a BC Epilepsy Society Research Award and the CURE—Taking Flight Award. B.A.M. was supported by the Canadian Institutes of Health Research (CIHR; #FDN148397) and by a Canada Research Chair in Neuroscience. S.R.A.A. currently receives funding from the National Institute of Neurological Disorders and Stroke (NIH 1UG3NS123958-01), the US Department of Defense (W81XWH-20-1-0930, HT9425-23-1-0330), and the Research Endowment fund of the Department of Anesthesiology and Critical Care Medicine, University of New Mexico School of Medicine. G.B.B. received funding from a University of Alberta Distinguished University Professor research allowance (PSY25) and a Canada Foundation for Innovation infrastructure grant."