Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.

"availability of data and materials normalized gene expression counts and somatic protein-altering mutations are available in geo with an accession number gse233034. availability of data and materials normalized gene expression counts and somatic protein-altering mutations are available in geo with an accession number gse233034"

"Declarations Ethics approval and consent to participateThe study was conducted in accordance with the principles of the Declaration of Helsinki. This study was approved by The Regional Ethics Committee of Tampere University Hospital (Tays) (decision R07042, date 20.9.2017) and Valvira (decision V/78697/2017). The requirement for informed consent was waived by The Regional Ethics Committee of Tampere University Hospital (Tays) because of the retrospective nature of the study. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Open access funding provided by Tampere University (including Tampere University Hospital). The study was financially supported by the Academy of Finland (#312043 (M.N.), #310829 (M.N.), #333545 (K.J.R.)), Cancer Foundation Finland (M.N., K.J.R.), Sigrid Jusélius Foundation (M.N., K.J.R.), Emil Aaltonen Foundation (K.J.R.), Finnish Cancer Institute (M.N.), Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (M.N., K.J.R.), Tampere University Faculty of Medicine and Health Technology (S.J.), Finnish Cultural Foundation (E.M.V.), Turku University Foundation (M.V.), and University of Turku Graduate School (M.V.). The results published here are in part based upon data generated by The Cancer Genome Atlas (TCGA) project established by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). TCGA rearrangement data were preprocessed by the International Cancer Genome Consortium (ICGC). We acknowledge the CSC—IT Centre for Science, Finland, for providing computational resources."