Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes.

"single-cell rna-sequencing data of the human chorioamniotic membranes were obtained from ncbi dbgap phs001886 v1 p1 as originally reported in.; single-cell rna-sequencing data of the murine tissues were obtained from the gene expression omnibus (gse200289) as originally reported in.; metagenomics files and associated metadata have been uploaded to the national center for biotechnology information's sequence read archive (prjna929530)."

"Declaration of interests The authors declare no competing interests."

"This research was supported by the Perinatology Research Branch (PRB), Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, 10.13039/100009633Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS) under Contract No. HHSN275201300006C. This research was also supported by the 10.13039/100006710Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health. R.R. has contributed to this work as part of his official duties as an employee of the United States 10.13039/100015539Federal Government. The authors gratefully acknowledge the members of the Biomarkers, Translational Science, and Microbiome Units of the PRB for their support with some molecular biology experiments. We also acknowledge Tzu Ning (Emily) Liu, a rotating medical student, who assisted with the set-up and validation of neurobehavioral tests in murine neonates."