Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish.

"Declarations Ethics approval and consent to participateAll studies were procedure in accordance with the guidelines of the Institutional Animal Care and Use Committee of the Inha University in Incheon (INHA 220719-832). Informed consent was obtained from all participants and their legal guardians, ensuring that they were fully informed about the study’s purpose, procedures, and potential risks, and that their participation was voluntary. Consent for publicationParticipants provided consent for the publication of the study’s findings, which includes the utilization of de-identified data and anonymous quotations. Competing interestsThe authors declare that they have no conflicts of interest with the contents of this article. Competing interests The authors declare that they have no conflicts of interest with the contents of this article."

"Funding This work was supported by National Research Foundation (NRF) of Korea Grants (RS-2023-00245023) and research grant of Inha University."