Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.

"Declarations Ethics approval and consent to participateThis study was approved by the Ethics Committee of Shantou Central Hospital. The use of clinical sample for scientific research and written informed consent were obtained from all participants. Consent for publicationWritten informed consent for publication was obtained from all participants. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by grants from the National Natural Science Foundation of China (Grant No.81902268 and 81974328), Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2022B1515020044), the Natural Science Foundation of Guangdong Province (2020A1515010207, 2022A1515010431 and 2022A1515011714), the China Postdoctoral Science Foundation (2019TQ0385 and 2019M663264), the Medical and Health Projects of Shantou Science and Technology Plan (190923175260442 and 220509156493840), and Guangdong Special Foundation for Science and Technology (190824115554543)."