Opposite effects of low-carbohydrate high-fat diet on metabolism in humans and mice.

"Declarations Ethics approval and consent to participate The study in human was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital. This trial was registered at www.chictr.org.cn with clinical trial registration number ChiCTR1800016786. All subjects provided written informed consent before enrollment. The animal study was reviewed and approved by the Animal Ethical and Welfare Committee of Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital and all the procedures were performed according to Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Guidelines for the Care and Use of Laboratory Animals. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (82070885), Shanghai Municipal Education Commission - Gaofeng Clinical Medicine Grant (20172025), Shanghai Research Center for Endocrine and Metabolic Diseases (2022ZZ01002) and Shanghai Municipal Key Clinical Specialty."

"Trial registration The clinical trial was registered with the Chinese Clinical Trial Registry (www.chictr.org.cn). The registration number is ChiCTR1800016786. All participants provided written informed consent prior to enrolment."