A phenome-wide approach to identify causal risk factors for deep vein thrombosis.

"scripts used to perform the analyses in this study are available on github at https://github com/andrewcon/dvt-mr ."

"Declarations Ethics approval and consent to participateUK Biobank received ethical approval from the NHS National Research Ethics Service North West (11/NW/0382; 16/NW/0274) and was conducted in accordance with the Declaration of Helsinki. All participants provided written informed consent before enrolment in the study. Ethical approval for ALSPAC was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act (2004). Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendations of the ALSPAC Ethics and Law Committee at the time. Consent for publication Consent for publication-not applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding AC acknowledges funding from grant MR/N0137941/1 for the GW4 BIOMED MRC DTP, awarded to the Universities of Bath, Bristol, Cardiff and Exeter from the Medical Research Council (MRC)/UKRI. NJT is the PI of the Avon Longitudinal Study of Parents and Children (Medical Research Council & Wellcome Trust 217065/Z/19/Z) and is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001). NJT acknowledges funding from the Wellcome Trust (202802/Z/16/Z). EEV, CJB, and NJT acknowledge funding by the CRUK Integrative Cancer Epidemiology Programme (C18281/A29019). NJT, EEV and CJB work in a unit funded by the UK Medical Research Council (MC_UU_00011/1 & MC_UU_00011/4) and the University of Bristol. EEV and CJB are supported by Diabetes UK (17/0005587) and the World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant program (IIG_2019_2009). LJG is supported by a BHF Accelerator Award Transition Fellowship (AA/18/1/34219). IH and SM acknowledge funding by the BHF (PG/16/3/31833 and PG/16/21/32083) and EPSRC Prostanoid programme (EP/M012530/1). SM acknowledges funding from the MRC. JZ is supported by Shanghai Thousand Talents Program and the National Health Commission of the PR China (SBF006\1117). CJB acknowledges funding from Health Data Research UK, an independent registered charity (number 1194431). BE acknowledges funding from Our Future Health, a company limited by guarantee registered in England and Wales (number 12212468) and a charity registered with the Charity Commission for England and Wales (charity number 1189681) and OSCR, Scottish Charity Regulator (charity number SC050917). The UK Medical Research Council and Wellcome (217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and EEV and IH will serve as guarantors for the contents of this paper. This research was funded in whole, or in part, by the Wellcome Trust (217065/Z/19/Z & 202802/Z/16/Z). For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf); This research was specifically funded by Wellcome Trust WT091310. This work was also supported by the Elizabeth Blackwell Institute for Health Research, University of Bristol, and the Wellcome Trust Institutional Strategic Support Fund (ISSF 204813/Z/16/Z). The funders of the study had no role in the study design, data collection, data analysis, data interpretation or writing of the report."