Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression.

"Declarations Ethics approval and consent to participateApproval of the research protocol by an Institutional Reviewer Board: All animal experiments were reviewed and approved by the Ethics Committee for Animal Experimentation of The Second Hospital of Shandong University (No. KYLL-2018(KJ) A-0046), in compliance with Institutional Animal Care and Use Committee guidelines. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). Consent for publicationNot Applicable. Competing interestsThe authors declare that they have no competing interest. Competing interests The authors declare that they have no competing interest."

"Funding This work was financially supported by the National Natural Science Foundation of China (82002431), and Fund of Jinan Municipal Bureau of Science and Technology under Grant (20228118)."