Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.

"affymetrix data are deposited at gene expression omnibus ( https://www ncbi nlm nih gov/geo/query/acc cgi ) with accession number gse244830. expanded materials and methods figures s1-s19 data set file major resources table full unedited gels references - nonstandard abbreviations and acronyms akt protein kinase b cdk cyclin-dependent kinase egfr epidermal growth factor receptor hap1 human near-haploid cell line hpasmc human pulmonary arterial smooth muscle cell ki knock-in mapk mitogen-activated protein kinase mtor mammalian target of rapamycin nox nadph oxidase p13k phosphoinositide 3-kinase pah pulmonary arterial hypertension pdgf platelet-derived growth factor ph pulmonary hypertension pkari?"

"Disclosures None."

"Sources of Funding O. Rudyk is supported by a British Heart Foundation Intermediate Basic Science Research Fellowship (FS/14/57/31138), British Heart Foundation Project Grant (PG/20/10427), and King’s British Heart Foundation center of Research Excellence (RE/18/2/34213). P. Eaton is supported by The Bart’s Charity Cardiovascular Program Award G00913 and by program grants from the British Heart Foundation and the Medical Research Council. Ralph Schermuly is supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project-ID 268555672—SFB 1213, project A08. This research was also supported by Research and Development, Guy’s and St Thomas’ National Health Service Foundation Trust. The views expressed are those of the authors and not necessarily those of the National Health Service."