Calorie restriction reduces biomarkers of cellular senescence in humans.

"CONFLICT OF INTEREST STATEMENT NKL and Mayo Clinic have intellectual property related to this work licensed to a commercial entity. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and is being conducted in compliance with Mayo Clinic Conflict of Interest policies."

"We thank the CALERIE™ investigators and CALERIE™ Biorepository (R33AG070455) for its support of this work. The work detailed here was supported by the National Institutes of Health (NIH), National Institute on Aging through R01 AG055529 and an accompanying administrative supplement, R56 AG060907, and P01 AG062413 to N.K.L., S.K., R01 AG076515 (S.K.); the National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (grants U01AG022132, U01AG020478, U01AG020487, U01AG020480, and R01AG071717); National Obesity Research Center (grant P30 DK072476), sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases; and the National Institute of General Medical Sciences of the National Institutes of Health, which funds the Louisiana Clinical and Translational Science Center (grant U54 GM104940). R.A.F. and S.K.D. partially supported by the US Department of Agriculture (USDA), under agreement No. 58‐8050‐9‐004. R.A.F. is partially supported by NIH Boston Claude D. Pepper Center (OAIC; 1P30AG031679). The authors also acknowledge the support of the Robert and Arlene Kogod Center on Aging and the Glenn Foundation for Medical Research. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the USDA."