Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

"availability of data and materials all proteomics raw files have been deposited in the pride database (proteomexchange consortium) with the data identifier pxd040251. custom-made contaminant protein libraries ( https://github com/haogroup-protcontlib ) were included in the data analysis pipeline to identify and remove contaminant proteins [ ]."

"custom-made contaminant protein libraries ( https://github com/haogroup-protcontlib ) were included in the data analysis pipeline to identify and remove contaminant proteins [ ]."

"Declarations Ethics approval and consent to participateAll mouse work and experiments in this study were approved by the NINDS/NIDCD/NCCAM Animal Care and Use Committee (ACUC). Consent for publicationAll authors have approved the manuscript and provided consent for publication. Competing interestsThe authors declare no competing financial interests. Competing interests The authors declare no competing financial interests."

"Funding This study is supported by the NIH grant (R01NS121608, Hao), GW intramural grant (UFF, Hao), the Intramural Research Program at NIH/NINDS (Ward), and MRC Dementias Platform UK Stem Cell Network Capital Equipment Awards MR/M024962/1 (Wade-Martins)."