Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson's disease.

"the video gait analysis software developed by the authors in python3 3 ('gaitanalyst') is provided open access in the github repository ( https://github com/dongchengli940126/keypressedtimevideorecord )."

"Declarations Ethics approval and consent to participateThis feasibility study sought to test if FOG-initiated (responsive) vibration cueing from a device worn on the lower legs can overcome FOG and improve walking in people with PD. The research project was conducted in accordance with the Declaration of Helsinki and was approved by the UK NHS Health Research Authority Southwest-Frenchay Research Ethics Committee (ref. 18/SW/0253). Eligible participants were willing and able to give informed consent for participation in the study and to comply with all study requirements, as well as being fluent in English, and with a clinical diagnosis of Parkinson’s disease or idiopathic Parkinson’s disease. Further details are provided under Methods. Consent for publicationAll participants consented to the publication of anonymised study data. Competing interestsAll authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: JC/DL/AH report grant funding from the Wellcome Trust and EIT Health (European Institute of Innovation and Technology) during the conduct of the study; JC/DL/AH are co-founders of, and report personal fees from, GaitQ Ltd., outside the submitted work; JC/DL report patent pending "Targeted cue delivery system for gait regulation"; All other authors declare they have no competing interests associated with their contribution to this manuscript. Competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: JC/DL/AH report grant funding from the Wellcome Trust and EIT Health (European Institute of Innovation and Technology) during the conduct of the study; JC/DL/AH are co-founders of, and report personal fees from, GaitQ Ltd., outside the submitted work; JC/DL report patent pending "Targeted cue delivery system for gait regulation"; All other authors declare they have no competing interests associated with their contribution to this manuscript."

"Funding This work was supported by funding from the Wellcome Trust (ISSF translational award) and EIT Health (proof-of-concept award)."

"This feasibility study was conducted in accordance with the Declaration of Helsinki and was approved by the UK NHS Health Research Authority Southwest-Frenchay Research Ethics Committee (ref. 18/SW/0253). The study was sponsored by the University of Oxford, and funded by a Wellcome Trust Institutional Strategic Support Fund Translational Award (ISSF 204826/Z/16/Z). The study was retrospectively registered with clinicaltrials.gov (NCT05019469; 23/08/2021). The study sessions were conducted between 11th March and 22nd July 2019 at a private physiotherapy studio in Cassington, Oxfordshire (The Bosworth Clinic) under a contract with the University of Oxford. During all study sessions, participants were closely supervised and supported by a qualified neurophysiotherapist."