A Conserved Ribosomal Protein Has Entirely Dissimilar Structures in Different Organisms.

"these structures included the models of s cerevisiae (pdb 4v88) v necatrix (pdb 6rm3) p locustae (pdb 6zu5) and e cuniculi (pdb 7qep) ribosomes. to address this we first searched for msl1/msl2 homologs in the ncbi genome database using a sensitive homolog search based on hidden markov models ( supplementary materials and methods supplementary material online; supplementary data s1 supplementary material online).; because this finding suggested that the h52 truncation was a major driver of the msl1- vn /msl2- ec fold switch we next assessed the length of h52 across microsporidian species ( fig 3a ; supplementary data s2 supplementary material online).; the obtained results from each of these searches were combined reduced to remove redundant findings and listed ( supplementary data s1 supplementary material online).; these sequences were then aligned using clustal omega with default parameters the resulting alignment is shown in ( supplementary data s2 supplementary material online)."

"Funding This work was funded by the Biotechnology and Biological Sciences Research Council BB/T008695/1 (to C.R.B.), the Newcastle University Oversears Research Scholarship 2021 award (to K.H-B.), the Swedish Research Council (2019-02011), the H2020 European Research Council (ERC Starting Grant PolTube 948655), the Science for Life Laboratory National Fellows program, and The Laboratory for Molecular Infection Medicine Sweden (all to J.B.) and the Horizon 2020 Framework programme (the Grant Agreement No. 895166 to S.V.M.)."