Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways.

"the sequencing data have been deposited in ncbi geo database: gse182235 ( https://www ncbi nlm nih gov/geo/query/acc cgi?"

"Declarations Ethics approval and consent to participateExperiments involving patient samples have been approved by the local Ethical Committee of Tianjin Third Central Hospital (SZX-IRB2020-005-02, Tianjin, China). Written informed consent was obtained from each patient according to the policies of the committee. The study methodologies were conformed to the standards set by the Declaration of Helsinki. All animals received humane care and complied with the approval for the use of laboratory animals by the Tianjin Medical University Animal Care and Use Committee (TMUaMEC2018025). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (32171125, 81971331 and 82170630)."