PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4.

"Declarations Ethics approval and consent to participateThe National Institutes of Health guidelines were followed strictly when performing all of the animal procedures. The Animal Care and Use Committee of Jinan University (Guangzhou, China; approval no. IACUC-20180726-03) approved all the animal procedures. Consent for publicationAll authors concur with the submission. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This study was supported by grants from the Natural Science Foundation of China (Nos. 82071568), the Guangdong Basic and Applied Basic Research Foundation (Nos. 2022A1515010842), the Science and Technology Program of Guangzhou (Nos. 202102010099 and SL2023A03J00699), the Administration of Traditional Chinese Medicine of Guangdong Province (Nos. 20202041), the Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University, China (Nos. JNU1AF-CFTP-2022-a01216), and the Guangzhou Key Laboratory for Germ-free animals and Microbiota Application (Nos. 202201020381)."