EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A.

"Declarations Ethics approval and consent to participateTen pairs of fresh frozen primary tumor tissues and corresponding adjacent normal tissues of HCC patients were obtained from Xijing Hospital (Xi’an, China), with the patients’ informed consent and the approval of the Medical Ethics Committee of First Affiliated Hospital of Fourth Military Medical University (approval number: KY20172013-1). All animal procedures were carried out according to the criteria outlined in the Guide for the Care and Use of Laboratory Animals prepared by the National Academy of Sciences and published by the National Institutes of Health (Bethesda, MD, USA) and were approved by the Laboratory Animal Ethics Committee of the Fourth Military Medical University (IACUC-20171005). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by grants from the National Natural Science Foundation of China (82172781 to J.P.L.; 82173046 to R.Z.; 82103202 to J.L.), Key Research and Development Project of Shaanxi Province (2020SF-229 to Y.L.L.), Shaanxi Innovative Research Team for Key Science and Technology (S2022-ZC-TD-0065 to R.Z.), and Shaanxi Province Funds for Distinguished Young youths (2023-JC-JQ-66 to R.Z.)."