Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury.

"Declarations Ethics approval and consent to participateHuman MSCs were initially raised from bone marrow samples of healthy donors after informed consent according to the Declaration of Helsinki. Animal experiments were performed in accordance with the Animal Research Reporting of in Vivo Experiments (ARRIVE) guidelines with governmental approval by the State Agency for Nature, Environment and Consumer Protection North Rhine-Westphalia. Consent for publicationNot applicable. Competing interestsBG is a scientific advisory board member of Innovex Therapeutics SL, Mursla Ltd and PL BioScience. He is a founding director of Exosla Ltd. All other authors report no conflicts of interest. Competing interests BG is a scientific advisory board member of Innovex Therapeutics SL, Mursla Ltd and PL BioScience. He is a founding director of Exosla Ltd. All other authors report no conflicts of interest."

"Funding Open Access funding enabled and organized by Projekt DEAL. This work was supported by a research grant from the European Society for Paediatric Research (ESPR) provided to NL (RGP2022-YISUG-02/04), the Else-Kröner-Fresenius-Stiftung (2018_A113) provided to JH, and the European Union [(Horizon 2020 Research and Innovation programme, Grant Agreement No. 874721, PREMSTEM) provided to UFM and IB, (European Regional Development Fund 2014–2020 and ERA-NET EuroTransBio 11 EVTrust, 031B0332B) provided to BG]."