Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.

"Declarations Ethics approval and consent to participateThe collection and propagation of PDAC patient samples were performed at different research institutions while adhering to ethical guidelines and informed consent procedures. The Spanish National Cancer Research Centre (CNIO), Madrid, Spain (reference 1204090835CHMH), the ARC-Net Biobank of the University and Hospital Trust of Verona, Italy (approved by the Verona University Hospital Ethics Committee, Program 1885 protocol 52438 23/11/2010, program 2172 protocol 26773 23/05/2012), and the Shanghai Jiao Tong University School of Medicine, Shanghai, China (reference 2013–0905-70) obtained appropriate informed consent from each patient before collecting samples.All animal procedures involving mice were performed in compliance with regulations concerning animals used in scientific research. The animal procedures in the UK were conducted under Project License PPL70/8129, while the Shanghai Jiao Tong University School of Medicine approved the project under project approval A-2020–004. Consent for publicationNot applicable. Competing interestsThe authors have no competing interests to disclose. Competing interests The authors have no competing interests to disclose."

"Funding This work was supported by the ERC Advanced Investigator Grant (Pa-CSC 233460, to CH), the European Community's Seventh Framework Programme (FP7) under grant agreement n° 602783 (CAM-PaC, to CH), the Fondazione del Piemonte per l’Oncologia – IRCCS (PTCRC-Intra-2021 to CH), the Shanghai Municipal Education Commission (2021–01-07–00-02-E00090, to CH), the National Natural Science Foundation of China (82130074 and 82250710179 to CH; 81902673, to QZ), the Ministry of Science and Technology, Taiwan (Grant number MOST 111–2314-B-039–056, to AA), Shanghai Pujiang Program (21PJ1408900, to JT), Associazione Italiana Ricerca Cancro IG n. 26343 (A.S.), and Fondazione Italiana Malattie Pancreas – Ministero Salute FIMP_CUP J37G22000230001 (RTL)."