Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation.

"data availability wgs and rna-seq data have been deposited at the european genome-phenome archive (accession number egas00001006965). data availability wgs and rna-seq data have been deposited at the european genome-phenome archive (accession number egas00001006965"

"Competing interests E.C. has been a consultant for Takeda, NanoString, AbbVie and Illumina; has received honoraria from Janssen, EUSPharma and Roche for speaking at educational activities and research funding from AstraZeneca and is an inventor on 2 patents filed by the National Institutes of Health, National Cancer Institute: “Methods for selecting and treating lymphoma types,” licensed to NanoString Technologies, and “Evaluation of mantle cell lymphoma and methods related thereof”, not related to this project. F.N. has received honoraria from Janssen, AbbVie, AstraZeneca and Sophia Genetics  for speaking at educational activities. D.C. has received honoraria from AbbVie, Sophia Genetics, Thermofisher  and AstraZeneca for speaking at educational activities. The remaining authors declare no competing financial interests."

"The authors want to thank the Hematopathology Collection registered at the Biobank of Hospital Clínic – Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCB-IDIBAPS) for sample procurement as well as to the CLL Genome Consortium (ICGC) and all patients who have participated in this study. We gratefully acknowledge Dr Estella Matutes for the review of cytology samples. We are in debt with the Flow Cytometry and Cell Sorting core facility and Genomics core facility of the Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCB-IDIBAPS) for their technical help. This study was supported by the Spanish Ministry of Science and Innovation (RTI2018-094584-B-I00 and PID2021-123165OB-I00 to D.C.) and was cofounded by the European Regional Development Fund (ERDF) and the CERCA program from Generalitat de Catalunya, CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB16/12/00334), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, and Generalitat de Catalunya [2017 SGR 1009]. H.P.-A. is a recipient of a predoctoral fellowship from the Spanish Ministry of Universities (grant number FPU19/03110). F.N. acknowledge research support the American Association for Cancer Research (2021 AACR-Amgen Fellowship in Clinical/Translational Cancer Research, 21-40-11-NADE), the European Hematology Association (EHA Junior Research Grant 2021, RG-202012-00245), the Lady Tata Memorial Trust (International Award for Research in Leukaemia 2021-2022, LADY_TATA_21_3223). This work was mainly developed at the Centre Esther Koplowitz (CEK) and the Animal Care Facility of University of Barcelona."