Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This work was supported by the 10.13039/501100012166National Basic Research Program of China (Grant No.: 2015CB553701) and the 10.13039/501100018537National Science and Technology Major Project, China (Grant No.: 2019ZX09732001). Jia-Jia Zhang: Methodology, Investigation, Formal analysis, Visualization, Writing - Original draft preparation; Chang-Geng Song: Methodology, Validation, Formal analysis, Visualization, Writing - Original draft preparation; Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, and Yu-Meng Zhu: Investigation, Writing - Reviewing and Editing; Zhi-Chuan Sun: Methodology, Writing - Reviewing and Editing; Ya-Zhou Wang, Jian-Li Jiang, and Ling Li: Methodology, Resources, Writing - Reviewing and Editing; Xiang-Min Yang: Conceptualization, Methodology, Resources, Formal analysis, Funding acquisition, Writing - Reviewing and Editing; Zhi-Nan Chen: Conceptualization, Supervision, Resources, Funding acquisition, Formal analysis, Writing - Reviewing and Editing."