Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice.

"data availability statement rna-seq and 16s rrna sequencing data are deposited at the nih gene expression omnibus (geo) under accession #gse237337. data availability statement rna-seq and 16s rrna sequencing data are deposited at the nih gene expression omnibus (geo) under accession #gse237337"

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"The authors would like to acknowledge 1R03CA234999 (JWC) for funding for this project. This project was also supported, in part, by the USDA Agricultural Research Service Cooperative Agreement 8050-51000-106-000-D (JWC and JBM). Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the USDA. In addition, the authors acknowledge 1S10OD032203-01 (Tufts University Core Facility Genomics Core) for the support of the included NGS analysis and S10OD030269 & S10OD026983 instrumentation (NAC) for supporting the microscopic analysis. Dr Donald Smith is thanked for his support and expert oversight of the vivarium and Ms Lucia Pham for her dedicated, tireless, and expert technical assistance. Dr Roderick T. Bronson is acknowledged for preparing tumor slides. Hans Gertje and Aoife O’Connell are acknowledged for their assistance in preparing tissue sections for IHC analysis. The Data Science Core of Boston University Chobanian & Avedisian School of Medicine is thanked for supporting the data analysis."