Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation.

"the top 10 metabolites closely associated with prert response are shown in figure 1f 10 1136/jitc-2023-007840 supp5 supplementary data 10 1136/jitc-2023-007840 supp6 supplementary data we performed a spearman correlation analysis to identify the metabolites closely associated with gut microbiota and the prert response."

"Competing interests: No, there are no competing interests."

"Funding: This research was funded by the Fujian Province Natural Science Foundation (No. 2021J01433, 2021J01438 and 2022J01433), the Fujian Province Joint Funds for the Innovation of Science and Technology (2021Y9216 and 2021Y9202). Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy (2020Y2012), Fujian Clinical Research Center for Radiation and Therapy of Digestive, Respiratory and Genitourinary Malignancies (2021Y2014), National Clinical Key Specialty Construction Program, Startup Fund for Scientific Research, Fujian Medical University (grant number 2020QH2043), Fujian Province Outstanding Youth Science Fund Projects (2022J06034); Natural Foundation of Fujian Province, Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare."