TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.

"Declarations Ethics approval and consent to participateAll animal care and experiments were conducted according to the Institutional Animal Care and Use Committee of Wenzhou Medical University, and all experiments were designed to minimize animal suffering. The study protocol was approved by the Animal Experiment Committee of Wenzhou Medical University (WYYY-AEC-2023-082). Competing interestsThe authors declare that there are no competing interests. Competing interests The authors declare that there are no competing interests."

"Funding This study was supported by the Natural Science Foundation of China (Nos. 82104622, 81603685), Zhejiang Medical and Health Science and Technology Project (Nos. 2022KY891, 2024KY1244, 2023RC045). Wenzhou Science and Technology Bureau Project (Nos. Y20220216, Y2021Y0713), Zhejiang Natural Science Foundation (Nos. LQ21H150007 and LY22H150003) and Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province."