Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials.

"Declarations Ethics approval and consent to participateThe study was approved by the ethics committee of the French Intensive Care Society (FICS/SRLF 23/036) and was conducted in compliance with the latest version of the Declaration of Helsinki and good clinical practice guidelines. The protocol of each of the four randomised controlled trials used for the study was approved by the appropriate ethics committee. In all four trials, written informed consent was obtained from surrogates of the comatose patients before inclusion. Competing interestsJBL has received lecturing fees from BD and Zoll. FST has received lecturing fees from BD and Zool. AMG has received reimbursement for travel expenses (TTM22 Boundaries of Temperature 9th international Targeted Temperature Management teaching course 27-28/6-2022, BD) and owns Novo Nordisk options. The other authors declare that they have no competing interests. Competing interests JBL has received lecturing fees from BD and Zoll. FST has received lecturing fees from BD and Zool. AMG has received reimbursement for travel expenses (TTM22 Boundaries of Temperature 9th international Targeted Temperature Management teaching course 27-28/6-2022, BD) and owns Novo Nordisk options. The other authors declare that they have no competing interests."

"Funding This study was funded solely by institutional sources."

"Conclusions: Early hyponatremia was common in patients with ROSC after cardiac arrest and was associated with a poorer 6-month functional outcome. The mechanisms underlying this association remain to be elucidated in order to determine whether interventions targeting hyponatremia are worth investigating.: Registration ClinicalTrial.gov, NCT01994772, November 2013, 21."