A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma.

"Declarations Availability of supporting dataAll the data employed in this study are comprehensively presented within the article, and availability upon reasonable request from the corresponding author is ensured. The relevant datasets can also be accessed through direct web links: TCGA: https://www.cancer.gov/ ; GTEx: https://commonfund.nih.gov/GTEx/ ; GDC: https://gdc.cancer.gov/ ; cBioPortal: https://www.cbioportal.org/ ; Kaplan–Meier Plotter: http://www.kmplot.com/analysis/ ; DAVID: https://david.ncifcrf.gov/ ; TIMER2.0: http://timer.cistrome.org/ ; Smartapp: www.bioinfo-zs.com/smartapp/; TISDB: http://cis.hku.hk/TISIDB/index.php. Ethics approval and consent to participateAll procedures were performed in accordance with the Declaration of Helsinki and approved by the ethics committee of the Hamadan university of medical sciences (IR.UMSHA.REC.1402.396). Informed consent was obtained from all subjects and or their legal guardians. Patient samples were collected from Poursina Hakim Research Institute (Esfahan, Iran). Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work is supported by a grant from Hamadan University of Medical Sciences, Hamadan, Iran (No. 140206215079)."