Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV).

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"We thank Dr. Avery August and Dr. Melanie Ragin for their support and mentorship of D.S. within the Howard Hughes Medical Institute Cornell University Research Transfer Program. A.C. is supported by grant T32EB023860 from the National Institute of Biomedical and Bioengineering. Work on coronavirus entry in the Whittaker lab is funded in part by the National Institute of Health research grant R01AI35270. Access to computational resources allocated by the COVID-19 High Performance Computing Consortium at the Oak Ridge Leadership Computing Facility, which is a DOE Office of Science User Facility supported under Contract DE-AC05-00OR22725, and the AiMOS supercomputer at the Center for Computational Innovations (CCI) of Rensselaer Polytechnic Institute (RPI) is gratefully acknowledged together with the in-house computational resources of the David A. Cofrin Center for Biomedical Information in the Institute for Computational Biomedicine at Weill Cornell Medical College."