S-SCAM is essential for synapse formation.

"sequence data have been deposited in ncbi's gene expression omnibus and are accessible through geo series accession number gse228093. detailed information about the sequences of the shrnas the mutations introduced into the rescue constructs and the complete conservation of the shrna targeted sequences between rat and mouse s-scam is summarized in supplementary data s3 .; primers are listed in supplementary data s2 .; rna levels of housekeeping genes including lactate dehydrogenase gapdh actin and neurofilament light and heavy chains were not changed ( figure 7 ; supplementary data s1 ).; overall 544 genes were differentially expressed by the reduction in s-scam levels ( figure 7b ; supplementary data s1 ).; on the other hand the expression of the majority of s-scam interaction partners was unaffected (e g axins erbb4 ?-catenin ?-catenin igsf9b psd95 tamalin stargazin synarfgef and others; see supplementary data s1 )."

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB, B1-1 to TD)."