Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial.

"Competing interests No relevant disclosures."

"Acknowledgements: The TAME trial is funded by grants from the National Health and Medical Research Council (Australia; APP1119855), the Health Research Board (Ireland; DIFA-2017-036), the Health Research Council of New Zealand (18/160), and an unrestricted investigator-initiated research grant from Baxter Healthcare. The funding bodies had no input into the design or conduct of the trial or into the statistical analysis plan, and they will have no input into analysis or reporting of results. The study is coordinated in Australia by the Australian and New Zealand Intensive Care Research Centre, in conjunction with the Irish Critical Care Clinical Trials Network (covering Ireland and Europe) and the Medical Research Institute of New Zealand. This study is endorsed by the Australian and New Zealand Intensive Care Society Clinical Trials Group, the Irish Critical Care Clinical Trials Group and the Australian Resuscitation Outcomes Consortium."

"Trial registration: Australian and New Zealand Clinical Trials Registry (ACTRN12617000036314p) and ClinicalTrials.gov (NCT03114033)."