Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner.

"Declarations Ethics approvalAll participants provided written informed consent approved by the institutional ethics committee of each ADNI participating institution. Competing interestsME and NF receive research funding from Eli Lilly, ME received consulting feeds from Eli Lilly. Competing interests ME and NF receive research funding from Eli Lilly, ME received consulting feeds from Eli Lilly."

"Funding Open Access funding enabled and organized by Projekt DEAL. The study was funded by grants from Deutsches Zentrum für Luft- und Raumfahrt (DLR, 01KU2203 to M. Ewers), Legerlotz (to M. Ewers). ADNI data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). L. Zheng received a scholarship from the China Scholarship Council (no. 202006240090). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California."