Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse.

"infection or overexpressing zip8 via ad-zip8 infection have been previously deposited in the gene expression omnibus under accession codes gse104793 (il-1?) gse104794 (hif-2?) and gse104795 (zip8)."

"Declarations Ethics approval and consent to participateNot applicable Consent for publicationNot applicable Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by grants to JSC from the National Research Foundation of Korea (2016R1A3B1906090). YS and HJK were supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2022R1IA1A01054359 to YS and 2022R1I1A1A01067323 to HJK). The funding body had no role in the study design, data collection, analysis, and interpretation of the data or writing of the manuscript."