Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis.

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This study was supported by grants from the Taiwan National Science Council [104-2314-B-002-125-MY3, 106-2314-B-002-166-MY3, 107-2314-B-002-026-MY3], National Health Research Institutes [PH-102-SP-09], National Taiwan University Hospital [106-FTN20, 106-P02, UN106-014, 106-S3582, 107-S3809, 107-T02,PC1246, VN109-09, 109-S4634, UN109-041] and Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) [MOST 106-2321-B-182-002, MOST 107-2321-B-182-004, MOST 108-2321-B-182-003, MOST 109-2321-B-182-001]. The funders had no role in study design, decision to publish, data collection and analysis or preparation of the manuscript."

"This systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) recommendation and Cochrane methods. The study protocol was registered in PROSPERO [CRD42023424693]."