Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design.

"data availability statement all sequencing data generated in the preparation of this manuscript have been deposited in the china national genebank database (cngbdb https://db cngb org/ ) with accession number cnp0002130 for 16s sequencing and cnp0004940 for metagenomic sequencing."

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"Author contributions: Y Wei and H Huang were responsible for the conceptualization of the study. Y Wei and X Liu were responsible for funding the acquisition. C Wang, G Ruan, Z Xiao, and F Xu, were responsible for the ethical approval and clinical trial registration. Y Tian and G Ruan were responsible for the preparation of FMT capsules. G Tan, X Hu, Z Xiao, Y Cheng, and P Yang were responsible for the follow-up of participants and data acquisition. Y Wei, H Huang, and D Chen were responsible for the supervision of the investigators working on this trial. Y Cheng, Q Zhu, S Ying, and J Qie were responsible for the statistical analysis and bioinformatics. Y Cheng and Q Zhu were responsible for the data visualization. Y Cheng and Q Zhu were responsible for the original draft writing. All authors contributed to the writing and review of the manuscript. All clinical data were accessed and verified by Y Wei and H Huang. All bioinformatics data were accessed and verified by Y Wei and X Liu. All authors can access all relevant data and accept responsibility for the submission of the study for publication. Y Cheng, G Tan, Q Zhu and C Wang contributed equally to this work."

"This randomized, placebo-controlled trial was carried out at the Department of Neurology, Army Medical University Southwest Hospital, from February 2019 to December 2019. The study was conducted in accordance with the guidelines and principles of the Declaration of Helsinki, approved by the Administrative Panel for Medical Research on Human Subjects (the Ethics Committee) of Army Medical University Southwest Hospital in Chongqing, China, and the trial registration number was ChiCTR1900021405 (http://www.chictr.org.cn/). Full protocol is presented in the Supplementary materials."