ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells.

"Declarations Ethics approval and consent to participateWe obtained ethical approval and adhered to institutional guidelines for using animals for scientific purposes. APAFIS#25871-20200522117321730. Human pericytes are from the cell line named HBPCT and were provided by professor Takashi Kanda's group from Yamagushi University (Japan). The study protocol was approved by local ethic committee and conducted in accordance with the declaration of helsinki, as amended in Somerset West in 1996. the collection and use of CD34+ stem cells derived from cord blood has been approved since 2011 by the research French ministry (CODECOH 2011-1321). The cells were harvested thanks to an agreement etablished between the hospital of Béthune (France) and Université of Artois, Lens (France). Informed consents were obtained from families before starting the study. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was support by University of Lille (JC & AVO PhD fellowships), Région Hauts de France (ST PhD fellowship), “Ligue contre le cancer” (Nord and Pas de Calais Committees), “Cancéropole Nord-Ouest”, Fondation pour la Recherche Médicale (EH phD fellowship), Rotary club International (Nieppe), CNRS & Japan Society for the Promotion of Science (JC research fellowship). This work is supported by a grant from “Contrat de Plan Etat-Région” CPER Cancer 2015–2020 and ONCOLille institute."